Daily dose of caffeine impairs recovery after noise-induced hearing loss

A new study by investigators at the Research Institute of the McGill University Health Centre (RI-MUHC) has discovered that daily consumption of caffeine can impair recovery after temporary hearing damage. The results are published in the Journal of the American Medical Association. Since both caffeine intake and noise related hearing loss are so common in our society, these findings could have a significant impact on the general population, especially for those who ingest high doses of caffeine regularly. 

Excessive noise is a serious health concern in many workplace environments, from the construction industry, to aviation, mining, and manufacturing. Concerts and other social events can also be an important source of noise, where sound levels may exceed health recommendations and can lead to hearing damage. 

Dr Faisal Zawawi

Dr Faisal Zawawi, Otolaryngologist and member of the McGill Auditory Sciences Laboratory at the RI-MUHC

"When the ear is exposed to loud noise, it can suffer from a temporary hearing reduction, also called auditory temporary threshold shift,” says Dr. Faisal Zawawi, an Otolaryngologist and member of the McGill Auditory Sciences Laboratory at the RI-MUHC led by Dr Sam J. Daniel. “This disorder is usually reversible in the first 72 hours after the exposure, but if symptoms persist, the damage could become permanent.”

Through their previous work, the researcher had come to suspect that certain substances, such as caffeine, might impact the ear’s ability to recover. Since caffeine intake is so common, especially in environments where noise can be a health hazard, they felt this potential link was worthy of further investigation.

The researchers used an animal model, exposing two groups to a sound of 110 dB – comparable to a loud rock concert – for a period of one hour. One group was administered a daily dose of caffeine, while the other remained caffeine-free. One day later the researchers found that hearing loss was similar in both groups. After eight days, the group without caffeine had recovered almost completely, while hearing impairment persisted in the group receiving daily caffeine. “Our research confirmed that exposure to loud auditory stimuli coupled with daily consumption of 25mg/kg of caffeine had a clear negative impact on hearing recovery,” says Dr. Zawawi.  Although further research is required to understand the effect on humans, the results are promising.

Caffeine is the most widely used psychoactive substance in the world. In Western society, at least 80 per cent of the adult population consumes caffeine in amounts large enough to have an effect on the brain. Caffeine is consumed in many different ways, including coffee, tea, soft drinks and energy drinks, and is even used in some medical treatments, such as the treatment for Apnea of Infancy, which involves caffeine and is administered to babies in Neonatal Intensive Care Units. The maximum recommended daily intake of caffeine of 3mg/kg – equivalent to three 8oz (237ml) cups of brewed coffee – is often exceeded. Some caffeinated energy drinks, particularly popular with teenagers and young adults, contain more than 200mg of caffeine.


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About the study: The study, “Association of Caffeine and Hearing Recovery After Acoustic Overstimulation Events in a Guinea Pig Model” was co-written Faisal Zawawi, MD, FRCSC; Aren Bezdjian, MSc; Mario Mujica-Mota, MD, MSc; Jamie Rappaport, MD, FRCSC; Sam Joseph Daniel, MD, MSc, FRCSC


Author Affiliations: Department of Otolaryngology–Head and Neck Surgery, McGill University, Montreal, Quebec, Canada


About the RI-MUHC: The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and healthcare research centre. The Institute, which is affiliated with the Faculty of Medicine of McGill University, is the research arm of the McGill University Health Centre (MUHC) – an academic health centre located in Montreal, Canada, that has a mandate to focus on complex care within its community. The RI-MUHC supports over 460 researchers and close to 1,300 research trainees devoted to a broad spectrum of fundamental, clinical and health outcomes research at the Glen and the Montreal General Hospital sites of the MUHC. Its research facilities offer a dynamic multidisciplinary environment that fosters collaboration and leverages discovery aimed at improving the health of individual patients across their lifespan. The RI-MUHC is supported in part by the Fonds de recherche du Québec – Santé (FRQS). rimuhc.ca 



Valérie Harvey
Public Affairs and Strategic Planning
McGill University Health Centre
[email protected]
Phone: (514) 934-1934 x71381