William Powell, PhD
Primary Axis:
Respiratory Health
Email:
Email contact form Research Focus:
Our research is focused on the role of eicosanoids in asthma and other inflammatory diseases. We discovered a pathway for the metabolism of arachidonic acid resulting in the formation of 5-oxo-ETE and we are investigating the regulation of its biosynthesis and its physiological role. This substance is a potent eosinophil chemoattractant and may contribute to the tissue infiltration of these cells in asthma. We have also identified a novel prostaglandin D2 receptor (the DP2 receptor/CRTH2) that is associated with eosinophil migration, and we are investigating its expression in the lung and its physiological role.Inflammation, asthma, eicosanoids, prostaglandins, leukotrienes
Keywords:
Inflammation, asthma, eicosanoids, prostaglandins, leukotrienes
Location:
Meakins-Christie Laboratories Publications:
Muro S, Hamid Q, Olivenstein R, Taha R, Rokach J, Powell WS. 5-Oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin. The Journal of Allergy and Clinical Immunology 2003; 112: 768-774.
Monneret G, Li HP, Vasilescu J, Rokach J, Powell WS. 15-deoxy-_12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. Journal of Immunology 2002; 168: 3563-3569.
Martin JG, Suzuki M, Maghni K, Pantano R, Ramos-Barbón D, Ihaku D, Nantel F, Denis D, Hamid Q, Powell WS. The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat. Journal of Immunology 2002; 169: 3963-3969.
