Vincent Giguère, MD, PhD

Primary Axis: 
Cancer
Email: 
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Research Focus: 

Study of the roles played by nuclear hormone receptors in metabolic diseases and cancer. Nuclear receptors are transcription factors that bind and respond to small lipophilic hormones (e.g. estrogens, androgens), vitamins A and D, fatty and bile acids and cholesterol metabolites. Deregulation of their activity has been implicated in numerous diseases, including heart failure, diabetes and cancer, and a large number of drugs targeting these receptors are currently used in the clinical setting. His laboratory employs of a wide array of molecular biology, mouse genetic and functional genomics related approaches to explore how nuclear receptors work at the molecular level and to identify their functions at the level of the whole organism.Nuclear receptors, transcription, hormones, vitamins, cancer, obesity, genetics, functional genomics, transgenic mice

Keywords: 
Nuclear receptors, transcription, hormones, vitamins, cancer, obesity, genetics, functional genomics, transgenic mice
Location: 
Montreal General Hospital
Publications:
Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguère V. Genome-wide orchestration of cardiac functions by orphan nuclear receptors ERRa and g. Cell Metabolism 5: 345-356; 2007.
Tremblay AM, Giguère V. The NR3B subgroup: An ovERRview. Nuclear Receptor Signaling 5: e009; 2007.
Laganière J, Deblois G, Lefebvre C, Bataille A R, Robert F, Giguère V. Location analysis of estrogen receptor a target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc. Natl. Acad. Sci. USA 102: 11651-11656; 2005.