Terence Coderre, PhD

Primary Axis: 
Neurosciences
Secondary Axis: 
Musculoskeletal Disorders
Email: 
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Research Focus: 

Studies are conducted on spinal cord and brain mechanisms of pain processing, as well as the mechanisms underlying opioid tolerance and dependence. Studies involve a multidisciplinary approach to neuroscience, including behavioural, neuropharmacological, neurochemical and neuroanatomical studies in laboratory animals. A primary focus is on the effect of persistent pain on the trafficking of spinal glutamate receptors, and the role of metabotrophic glutamate receptors in the regulation of spinal glutamate release, and how this regulation is affected by persistent pain. A secondary focus is the development of animal models of persistent and chronic pain.Pain, Nociception, Spinal Cord Plasticity, Neuropathic Pain, Inflammation, Excitatory Amino Acids, Metabotropic Glutamate Receptors, Hyperalgesia, Allodynia, Opioid Tolerance, Opioid Dependence

External Website: 
External Website
Keywords: 
Pain, Nociception, Spinal Cord Plasticity, Neuropathic Pain, Inflammation, Excitatory Amino Acids, Metabotropic Glutamate Receptors, Hyperalgesia, Allodynia, Opioid Tolerance, Opioid Dependence
Location: 
McIntyre Medical Building
Publications:
Xanthos DN, Coderre TJ. Sympathetic vasoconstrictor antagonism and vasodilatation relieve mechanical allodynia in rats with chronic post-ischemia pain. J Pain 9: 423-433; 2008.
Coderre TJ, Kumar N, Lefebvre CD, Yu SCC. A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine and riluzole in a model of neuropathic pain. J Neurochem 100: 1289-1299; 2007.
Pitcher MH, Ribiero-da-Silva A, Coderre TJ. Effects of persistent peripheral inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. J Comp Neurol 505: 412–423; 2007.