Steven Paraskevas, MD, PhD
Primary Axis:
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Email:
Email contact form Research Focus:
Work focuses on the biology of pancreatic beta-cells in the context of islet transplantation for type 1 diabetes: specifically, the influence of cellular microenvironment on cell death and survival, the role of cytokines produced during islet purification on graft function and immunogenicity, and the maintenance of islet differentiation. Other projects in the field of diabetes and transplantation include the development of predictive algorithms for beta-cell dysfunction base on non-linear dynamics and the development of the clinical islet transplant program at McGill.Islet, transplantation, diabetes, cell signaling
Keywords:
Islet, transplantation, diabetes, cell signaling
Location:
Royal Victoria Hospital Publications:
Paraskevas S, Aikin R, Maysinger D, Lakey JRT, Cavanagh TJ, Agapitos D, Wang R, Rosenberg L. Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: Insulin as an autocrine survival signal. Annals of Surgery 2001; 233:124.
Paraskevas S, Maysinger D, Wang R, Duguid WP, Rosenberg L. Cell loss in isolated human islets occurs by apoptosis. Pancreas 2000; 20:270.
Paraskevas S, Aikin R, Maysinger D, Lakey JRT, Cavanagh TJ, Hering B, Wang R, Rosenberg L. Activation and expression of ERK, JNK and p38 in isolated islets of Langerhans: Implications for cultured islet survival. FEBS Letters 1999; 455:203.
