Simon Sipen Wing, MD
Primary Axis:
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Secondary Axis:
Human Reproduction and Development Research Focus:
To explore the function and regulation of ubiquitin dependent proteolysis in mammalian tissues. Current projects explore the roles of the ubiquitin system in muscle wasting in various conditions such as cancer as well as the role of this system in spermatogenesis / fertilization and in circadian rhythym.
Keywords:
Intracellular proteolysis, ubiquitin, protein metabolism, spermatogenesis, muscle wasting, fertilization, circadian rhythym
Location:
Strathcona Anatomy and Dentistry Publications:
Bedard N, Yang Y, Gregory M, Cyr DG, Suzuki J, Yu X, Clarke H, Chian RC, Hermo L, O’Flaherty C, Smith CE and Wing SS. Mice Lacking the USP2 Deubiquitinating Enzyme have Severe Male Sub-Fertility Associated with Defects in Fertilization and Sperm Motility. Biol. Repro; 85: 594-604; 2011
Sundaram P, Pang Z, Miao M, Yu L and Wing SS. USP19 Deubiquitinating Enzyme Regulates Levels of Major Myofibrillar Proteins in L6 Muscle Cells. Amer. J. Physiol. Endo & Metab 297: E1283-E1290; 2009
Lu Y, Adegoke OAJ, Nepveu A, Nakayama KI, Bedard N, Cheng, D and Wing SS. USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1. Mol. Cell. Biol; 29: 547-558; 2009
Liu Z, Oughtred R, and Wing SS. Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Mol. Cell. Biol; 25: 2819-2831; 2005
Bedard N, Hingamp P, Pang Z, Karaplis A, Morales C, Trasler J, Cyr D, Gagnon C, and Wing SS. Mice lacking the UBC4-testis gene have a delay in postnatal testis development, but normal spermatogenesis and fertility. Mol. Cell. Biol; 25: 6346-6354; 2005
