Simon Rousseau, PhD
Primary Axis:
Respiratory Health
Secondary Axis:
Infection and Immunity
Email:
Email contact form Research Focus:
Research focuses on understanding the intracellular signals regulating inflammation in response to bacterial infections, in order to devise novel strategy to re-establish a balanced inflammatory response in lung diseases, such as Cystic Fibrosis.
External Website:
External Website Keywords:
Cystic Fibrosis, bacterial infections, Signal transduction, Protein Phosphorylation, Inflammation, Airway epithelium, Macrophages, Cytokines, Cell motility, Pathogens and Lung diseases
Location:
Meakins-Christie Laboratories Publications:
Roussel L, Martel G. Bérubé J and Rousseau S. P. aeruginosa drives CXCL8 synthesis via redundant Toll-like Receptors and NADPH oxidase in CFTR∆F508 airway epithelial cells. Journal of Cystic Fibrosis, 10:107-13; 2011
Bérubé J, Roussel L, Nattagh L, Rousseau S. Loss of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) function enhances p38 and ERK MAPKs activation increasing IL-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. Journal of Biological Chemistry, 285 : 22299-307.
Highlighted by the Faculty of 1000-Medicine as a must-read paper (Barrett K: 2010. F1000.com/3992957); 2010
Roussel L, Houle F, Chan C, Yao Y, Bérubé J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, Rousseau S. IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment in vivo. Journal of Immunology, Apr 15;184 (8):4531-7; 2010
Rousseau S, Papoutsopoulou M, Symons A, Cook D, Lucocq JM, Prescott AR, O'Garra A, Ley SC, Cohen P. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci 121(Pt 2): 149-154; 2008
Yang HT, Cohen P, Rousseau S. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell Signal 20(2): 375-380; 2008
Rousseau S, Morrice N, Peggie M, Campbell DG, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J 21(23): 6505-6514; 2002
