Serge Lemay, MD
Primary Axis:
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Email:
Email contact form Research Focus:
Acute kidney injury (AKI) is a very common and deadly problem in hospitalized patients.Research seeks to better define the molecular basis of kidney cell injury and repair, particularly the role of special enzymes called tyrosine kinases and the signals they trigger inside injured cells.
Keywords:
Acute kidney injury, ischemia-reperfusion injury, cell signaling, Eph receptors, adapter proteins, tyrosine kinases, epithelial cells, kidney
Location:
Duff Medical Building Publications:
Du X, Baldwin C, Hooker E, Glorion P, and Lemay S. Src kinase-mediated activation of the EphA2 promoter requires a cAMP-responsive element but is CREB-independent. J Cell Biochem, 112: 1268-1276; 2011
Gérard A, Ghiotto M, Fos C, Guittard G, Compagno D, Galy A, Lemay S, Olive D and Nunès JA. Dok-4 is a novel negative regulator of T cell activation. J Immunol; 182: 7681-7689; 2009
Baldwin C, Bedirian A, Li H, Takano T and Lemay S. Identification of Dok-4b, a Dok-4 splice variant with enhanced inhibitory properties. Biochem Biophys Res Comm; 354: 783-788; 2007
Baldwin C, Chen ZW, Bedirian A, Yokota N, Nasr SH, Rabb H, and Lemay S. Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases. Am J Physiol (Renal Physiol); 291: F960-F971; 2006
Bedirian A, Baldwin C, Abe J, Takano T, and Lemay S. PH and PTB domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. J Biol Chem; 279: 19335; 2004
