Samuel David, PhD

Primary Axis: 
Neurosciences
Email: 
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Research Focus: 

Research focuses on three areas: (1) Studying the genes and molecules that regulate inflammation after spinal cord injury; and developing therapeutic strategies to reduce inflammation and improve outcome after spinal cord damage. (2) Studying the role of the enzyme phospholipase A2 in the pathogenesis of multiple sclerosis and testing of small molecule inhibitors to treat multiple sclerosis. (3) Studying the molecular control of iron homeostasis in the nervous system, and the disruption and involvement of these mechanisms in neurodegenerative diseases such as amyotrophic lateral sclerosis and multiple sclerosis.Neurology & neurosurgery, CNS regeneration, spinal cord injury, multiple sclerosis, neurodegenerative diseases, inflammation in CNS, iron metabolism in brain and spinal cord

External Website: 
External Website
Keywords: 
Neurology & neurosurgery, CNS regeneration, spinal cord injury, multiple sclerosis, neurodegenerative diseases, inflammation in CNS, iron metabolism in brain and spinal cord
Location: 
Montreal General Hospital
Publications:
Fry E, Ho C, David S. A role for Nogo receptor in macrophage clearance from injured peripheral nerve. Neuron 53: 649-662; 2007.
Jeong SY, David S. Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice. J Neurosci 26: 9810-9819; 2006.
Kalyvas A, David S. Cytosolic phospholipase A2 plays a key role in the pathogenesis of MS-like disease. Neuron 41: 323-335; 2004.