Salvatore Carbonetto, PhD
Primary Axis:
Neurosciences
Email:
Email contact form Research Focus:
Dystroglycan forms the functional core of a complex of proteins that is associated with dystrophin. Mutations that affect dystrophin and dystroglycan lead to muscular dystrophies and mental retardation. My lab is using cellular, biochemical (proteomic) and genetic methods to study the function of dystroglycan in synapse formation, vesicle recycling and cell death. Understanding these fundamental processes will help in devising strategies to mitigate their dysfunction in muscular dystrophies and mental retardation.Synapse formation, dystrophin associated proteins, dystroglycan, vesicle recycling, cell death
Keywords:
Synapse formation, dystrophin associated proteins, dystroglycan, vesicle recycling, cell death
Location:
Montreal General Hospital Publications:
Montanaro F, Carbonetto S. Targeting dystroglycan in the brain. Neuron 2003; 37:193-196.
Côte P, Moukhles H, Lindenbaum M, Carbonetto S. Chimeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses. Nature Genetics 1999; 23:338-342.
Gee S, Montanaro F, Lindenbaum M, Carbonetto S. Dystroglycan alpha, a dystrophin associated glycoprotein, is a functional agrin receptor. Cell 1994;77: 675-686.
