Salman Qureshi, MD
Primary Axis:
Cardiovascular Diseases and Critical Care
Email:
Email contact form Research Focus:
Research focuses on identifying and characterizing the molecular and cellular mechanisms of inflammation and innate immunity that are relevant to human critical illness. Active research programs on host resistance against Cryptococcus neoformans, an opportunistic fungal pathogen that causes pneumonia and meningitis, Streptococcus pneumoniae/Klebsiella pneumoniae, two common bacterial pathogens that cause pneumonia and sepsis, and H1N1 influenza virus are ongoing.
External Website:
External Website Keywords:
Sepsis, pneumonia, genetic analysis, complex traits, toll-like receptors, innate immunity, chemical mutagenesis, transgenic mouse, Cryptococcus neoformans, influenza, Streptococcus pneumoniae
Publications:
Lafferty, E.I., Qureshi, S.T., Schnare, M. Toll-like receptors in acute and chronic pulmonary inflammation J Inflamm (Lond). 7(1):57;[Epub ahead of print]; 25 Nov 2010
Richer, E., Prendergast, C., Zhang, D. E., Qureshi, S. T., Vidal, S. M., Malo, D. N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-alphabeta signaling and suppresses STAT4-induced IFN-gamma production, resulting in increased susceptibility to Salmonella Typhimurium. J Immunol. 2010 Sep 15;185(6):3593-601; Epub Aug 6 2010
Paun, A., Fox, J., Balloy, V., Chignard, M., Qureshi, S. T., Haston, C. K. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Int J Radiat Oncol Biol Phys. 77(4):1198-205; 15 Jul 2010
Cyr, S.L., **Angers, I., *Guillot, L., Stoica-Popescu, I., Lussier, M., Qureshi S.T., Burt, D.S., Ward, B.J. TLR4 and MyD88 control protection and pulmonary granulocytic recruitment in a murine intranasal RSV immunization and challenge model Vaccine 27(3): 421-430; 2009
Bousette, N., D’Orleans-Juste, P., Kiss, R.S., You, Z., Genest, J., Al-Ramli, W., Qureshi, S.T., Gramolini, A., Behm, D, Ohlstein, E. H., Harrison, S.M., Douglas, S.A., Giaid, A. Urotensin II Receptor Knockout Mice on an ApoE Knockout Background fed a high-fat diet exhibit enhanced hyperlipidemic and atherosclerotic phenotype Circ Res 105(7):686-695; 2009
Guillot L, Carroll SF, Homer RJ, and Qureshi ST. Enhanced pulmonary innate immune responsiveness to Cryptococcus neoformans is associated with resistance to progressive infection Infect Immun 76(10):4745-4756; 2008
