Rolando Fausto Del Maestro, MD, PhD
Primary Axis:
Neurosciences
Email:
Email contact form Research Focus:
To characterize the invasive paradigms used by malignant glial cells to invade three-dimensional matrices using time-lapsed video microscopy;To delineate the genetic and biochemical determinants of these invasive paradigms; To develop novel chemotherapeutic approaches to target these invasive subpopulations of malignant cells. The questions that are being addressed are: 1. What paradigms do malignant brain tumour cells use to invade three dimensional structures? 2. What mechanisms are used by these cells during the invasive process? 3. What factors are involved in their invasion?Malignant Glial Tumours; Brain Tumour Invasiveness; Brain Tumour Tissue Banking; History of Medicine; Leonardo da Vinci.
External Website:
External Website Keywords:
Malignant Glial Tumours; Brain Tumour Invasiveness; Brain Tumour Tissue Banking; History of Medicine; Leonardo da Vinci.
Location:
Montreal Neurological Institute and Hospital Publications:
Amiez C, Kostopoulos P, Champod A-S,Collins L, Doyon J, Del Maestro RF, Petrides M. Pre-operative functional magnetic imaging assessment of higher order cognitive function in patients undergoing surgery for brain tumour. J.Neurosurg 108: 258-268; 2008.
Mason W, Del Maestro R, Eisenstat, D, Forsyth P, Fulton D, Laperrière N, Macdonald D, Perry J, Thiessen B. Canadian Recommendations for the treatment of glioblastoma multiforme. Practice Guideline Series, Current Oncology, 14:110-117; 2007.
Werbowetsky-Ogilvie TE, Agar NYR, Waldkircher de Oliveira RM, Faury D, Antel JP, Jabado N, Del Maestro RF. Isolation of a natural inhibitor of human malignant glial cell invasion: Inter α- trypsin inhibitor heavy chain 2. Cancer Res 66:1464-1472; 2006.
