Richard Kremer, MD, PhD
My research focuses on the role of calcium regulating hormones in health and disease. Over the past twenty years my laboratory has explored the role of vitamin D and parathyroid hormone related peptide (PTHrP) in cancer and musculoskeletal disorders. We were the first to establish the efficacy of vitamin D in reducing the skeletal complications of breast cancer and more recently in demonstrating the importance of the vitamin D activating enzyme, 1-alpha-hydroxylase expressed in mammary epithelial cells, in the prevention of breast cancer. We were also the first laboratory to demonstrate the in vivo efficacy of vitamin D on bone aging and prevention of fat accumulation in the bone marrow. Recently, we co-authored the first evidence linking vitamin D insufficiency and muscle fat accumulation. We were also the first laboratory to establish the role of PTHrP as a biomarker of survival in cancer and more recently as a critical mediator of tumor initiation and progression in breast cancer. My clinical research unit also participates in major multicenter trials on osteoporosis and bone–related cancer trials.