Pnina Brodt, PhD
Primary Axis:
Cancer
Email:
Email contact form Research Focus:
Research areas focus on signal transduction mechanisms of the IGF-I receptor, gene therapy strategies for metastatic malignancies, host-tumor interaction in metastasis, angiogenesis and lymphangiogenesis, and molecular mechanisms of tumor dormancy.Cancer metastasis, gene therapy, signaling, IGF-I receptor, angiogenesis
Keywords:
Cancer metastasis, gene therapy, signaling, IGF-I receptor, angiogenesis
Location:
Royal Victoria Hospital Publications:
Navab R., Pedraza C., Fallavollita F., Wang N., Chevet E., Auguste P., Jenna S., You Z., Bikfalvi A., Hu J, Erickson A, O’Connor R., Mort J. and Brodt P. Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels. Oncogene 27:4973-85, 2008.
Wang N., Fallavollita L., Nguyen L., Burnier J., Rafei M., Galipeau J. Yakar S., and Brodt P. Autologous bone marrow derived mesenchymal stromal cells genetically engineered to express an IGF-I receptor decoy prevent the growth of liver metastases. Mol. Ther, 17:1241-9, 2009.
Wu Y., Brodt P., Sun H., Mejia W., Novosyadlyy R., Mendoza A., Hong S-H., Khanna C., and Yakar S. IGF-1 regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Research 70 :57-67, 2010.
