Paul Goodyer, MD
Primary Axis:
Human Reproduction and Development
Secondary Axis:
Medical Genetics and Genomics Research Focus:
Research interests are in the molecular control of renal development as it pertains to hereditary renal disease. Lab themes include: a) common variants of genes that set nephron number during embryogenesis; b) the pathogenesis of Wilms tumor; c) the developmental aspects of polycystic kidney disease; d) paracrine mechanism in stem cell therapy of cystinosis; e) biology of renal progenitor cells. Clinical research focuses on renal hypoplasia due to maternal Vitamin A deficiency in India and the pathogenesis of focal segmental glomerulosclerosis.
Keywords:
Pediatric Nephrology, Hereditary renal disease, Kidney development, Stem cells, WNT signaling, Cystinosis, PKD, FSGS, Renal Hypoplasia
Location:
Montreal Children's Hospital Publications:
Miller MM, Iglesias DM, Zhang Z, Corsini R, Chu LL, Murawski I, Gupta I, Somlo S, Germino GG and Goodyer PR. T-Cell Factor/β-Catenin Activity is Suppressed Normally in Two Independent Models of Autosomal Dominant Polycystic Kidney Disease. Kidney Int. 2011 Jul; 80(2):146-53. doi: 10.1038/ki.2011.56; Epub Mar 9 2011
Zhang Z, Iglesias D, Eliopoulos N, El-Kares R, Chu LL, Romagnani P and Goodyer P. A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function. Hum Mol Genet. 2011 Nov 1;20(21):4167-74; Epub Aug 5 2011
Zhang Z, Pascuet E, Hueber P-A, Chu LL, Bichet DG and Goodyer P. Targeted inactivation of EGF receptor inhibits renal collecting duct development and renal concentrating ability in adult mice, J Am Soc Nephrol; [Epub ahead of print] Feb 4 2010
Mauer M, Zinman B, Gardiner R, Suissa S, Sinaiko A, Strand T, Drummond K, Donnelly S, Goodyer P, Gubler MC, Klein R. Effects of Enalapril and Losartan on Nephropathy and Retinopathy in Type 1 Diabetic Patients. N Engl J Med 361:40-51; 2009
Zhang Z, Quinlan J, Lemire M, Hudson T, Hueber P-A, Chu LL, Benjamin A, Roy A, Pascuet E, Goodyer M, Raju C, Houghton F and Goodyer P. A common RET variant is associated with reduced kidney size and function in normal newborns. In press, Journal of the American Society of Nephrology; 2008
Iglesias D, Hueber P-A, Chu LL, Campbell R, Patenaude A-M, Dziarmaga A, Quinlan J, Stayner C, Othman M, Dufort D and Goodyer P. Canonical WNT signaling during kidney development. Am J Physiol Renal Physiol. [Epub ahead of print] PMID: 17494089; May 9 2007
