Morag Park, PhD

Primary Axis: 
Cancer
Secondary Axis: 
Medical Genetics and Genomics
Research Focus: 

Reseach focuses on understanding the molecular events that occur during cancer progression and invasion with a focus on breast cancer. Using in vitro cell biology and animal models in addition to genomics-based strategies using microdissected breast cancer tissue.

Keywords: 
Breast cancer, cell models, cell migration and invasion, signal transduction, genomics and proteomics, receptor tyrosine kinase
Location: 
Rosalind and Morris Goodman Cancer Research Centre
Publications:
Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, Chen H, Omeroglu G, Meterissian S, Omeroglu A, Hallett M, Park M. Stromal gene expression predicts clinical outcome in breast cancer. Nature Medicine 14: 518-527; 2008.
Peschard P, Kozlov G, Lin T, Mirza A, Berghuis AM, Lipkowitz S, Park M, Gehring K. Structural basis for Ubiquitin-mediated dimerization and activation of the Ubiquitin protein ligase Cbl-b. Molecular Cell 27: 474-485; 2007.
Sangwan V, Paliouras GN, Cheng A, Dubé N, Tremblay ML, Park M. Protein-tyrosine Phosphatase 1B Deficiency Protects against Fas-induced Hepatic Failure. J Biol Chem 281 (1): 221-228; 2006.