Michael Barry Reed, PhD
Primary Axis:
Infection and Immunity
Email:
Email contact form Research Focus:
Our research focuses on the pathogenesis of Mycobacterium tuberculosis, the causative agent of the infectious disease, tuberculosis (TB). Over recent years, it has become evident that considerable genetic diversity exists amongst clinical TB isolates and we are interested in understanding the impact of this diversity on disease pathogenesis. Increasing our knowledge of variably expressed metabolic pathways and virulence mechanisms employed by M. tuberculosis may ultimately shed light on novel ways to diagnose and prevent TB transmission and disease.
Keywords:
Tuberculosis, bacterial pathogenesis, host-pathogen interactions, lipids
Publications:
Fallow A, Domenech P & Reed MB. Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants. Journal of Bacteriology 192: 2228-2238; 2010.
Coulombe F, Divangahi M, Veyrier F, Gleason J, Yang Y, Kelliher MA, Pandey AK, Sassetti CM, Reed MB & Behr MA. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. The Journal of Experimental Medicine 206: 1709-1716; 2009.
Reed MB, Pichler VK, McIntosh F, Mattia A, Fallow A, Masala S, Domenech P, Zwerling A, Thibert L, Menzies D, Schwartzman K & Behr MA. Major Mycobacterium tuberculosis lineages associate with patient country of origin. Journal of Clinical Microbiology 47: 1119-1128; 2009.
