Mara Ludwig, MD

Extracellular matrix in diseases characterized by remodelling such as asthma and pulmonary fibrosis. The effect of mechanical and cytokine stimulation on production of matrix molecules, in particular, proteoglycans. The contribution of proteoglycans to the mechanical characteristics of the lung parenchyma. Research techniques used include:animal models, whole animal physiology, in vitro measurements, histology, immunohistochemistry, protein extraction, Western blotting, real time PCR, structure-function correlation.Extracellular matrix, proteoglycans, remodeling, mechanotransduction, pulmonary fibrosis, asthma