Manuel Cosio, MD

Primary Axis: 
Respiratory Health
Email: 
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Research Focus: 

Research focuses on pathophysiology, inflammatory mechanisms and molecular genetics of COPD and pulmonary fibrosis in mouse models of cigarette smoke induced emphysema and /or fibrosis. In resistant and susceptible mouse strains to the development of emphysema and/or fibrosis we apply investigative pathology and morphometry, pulmonary physiology, and definition of the cellular inflammatory response and associated inflammatory mediators for the phenotyping of the disease. Gene microchip and QTL (quantitative trait loci) technologies are then applied for the investigation of genetic determinants of resistance and susceptibility to developing either disease or no disease.COPD, Emphysema, Mice models, T cells, Cytokines, Elastance, Genetics, Pathophysiology, Pathogenesis

Keywords: 
COPD, Emphysema, Mice models, T cells, Cytokines, Elastance, Genetics, Pathophysiology, Pathogenesis
Location: 
Royal Victoria Hospital
Publications:
Takubo Y, Guerassimov A, Ghezzo H, Triantafillopoulos A, Bates JHT, Hoidal J, Cosio MG. Alpha-1 antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human diseases. American Journal of Respiratory and Critical Care Medicine 2002; 166: 1596-1603.
Majo J, Ghezzo H, Cosio MG. Lymphocyte Population and Apoptosis in the lungs of smokers and their relation to emphysema. The European Respiratory Journal 2001;17: 946-953.
Finkelstein R, Fraser RS, Ghezzo H, Cosio MG. Alveolar inflammation and its relation to emphysema in smokers. American Journal of Respiratory and Critical Care Medicine 1995; 152: 1666-1672.