Lorenzo Edwin Ferri, MD, PhD

Esophageal cancer is associated with poor long-term survival due a high rate of early metastases. It is generally accepted that cell adhesion molecules (CAMs) play a central role in metastasis generationthe process of metastatic tumor spread and there is there is emerging data to which suggest that altered expression of surface and soluble CAMs may influence recurrence in some cancers. The predominant mechanisms of metastasis in esophageal cancer is poorly understood.Accordingly, the current research program aims to identify the mechanismsof esophageal cancer metastases, with particular focus on the central rolethat cell adhesion molecules and the host immune response play in themetastatic process.Esophagus cancer, metastasis, migration, intravital microscopy, selectin, cell adhesion molecules