Jun-Li Liu, PhD
Primary Axis:
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Email:
Email contact form Research Focus:
To explore novel growth factors that can be used to expand or preserve the islet beta cells, which make the key hormone insulin, against onset of diabetes mellitus. Our current focus is on a family of proteins normally produced in the pancreas, some having been shown the effectiveness in rodent models of the disease.
External Website:
External Website Keywords:
Growth and development, transgenic mice, Cre/loxP system, insulin-like growth factor, Reg family proteins, pancreatic islets, growth hormone
Location:
Royal Victoria Hospital Publications:
X Xiong, X Wang, B Li, S Chowdhury, Y Lu, CB Srikant, G Ning, JL Liu. Pancreatic isletspecific overexpression of Reg3β protein induced the expression of pro-islet genes and protected mice against streptozotocin-induced diabetes mellitus. Am J Physiol-Endo Metab; 300: E669-680; 2011
K Robertson, Y Lu, B Li, Q Su, PK Lund, JL Liu. A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia and significant resistance to experimental diabetes. Amer J Physiol-Endo Metab 294: E928-938; 2008
Y Lu, PL Herrera, Y Guo, D Sun, Z Tang, D LeRoith, and JL Liu. Pancreatic specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes. Diabetes; 53: 3131-3141; 2004
