John Kimoff, MD

Primary Axis: 
Respiratory Health
Research Focus: 

Current research activities include pathophysiologic and immunobiologic studies on the mechanisms of upper airway neuromuscular dysfunction in obstructive sleep apnea; studies on cardiovascular interactions in sleep-disordered breathing, including participation in a multi-centre trial on treatment of sleep-disordered breathing in patients with congestive heart failure, and a local study on pre-eclampsia and sleep-disordered breathing; and clinical studies on the interactions of asthma and sleep-disordered breathing and on novel clinical associations and innovative treatment approaches for obstructive sleep apnea.Sleep, Apnea, Control of breathing, Upper airway, Cardiovascular interactions, Inflammation

Keywords: 
Sleep, Apnea, Control of breathing, Upper airway, Cardiovascular interactions, Inflammation
Location: 
Royal Victoria Hospital
Publications:
Boyd JH, Petrof BJ, Hamid Q, Fraser R, Kimoff RJ. Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. American Journal Respiratory Critical Care Medicine 2004.
Rudkowski JP, Verschelden RJ. Kimoff. Efficacy of daytime nasal CPAP titration in severe obstructive sleep apnea. European Respiratory Journal 2001; 18: 535-541.
Kimoff RJ, Sforza E, Champagne V, Ofiara L, Gendron D. Upper airway sensation in snoring and obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine 2001; 164: 250-255.