John Hanrahan, PhD

Our research focuses on transport and signalling in epithelial tissues, particularly the mechanisms by which mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a tightly regulated chloride channel, lead to the disease cystic fibrosis. Another interest is in the mechanisms of cellular ATP release and their regulation by mechanical and other stimuli during autocrine and paracrine signalling by airway and other epithelial cells. The laboratory uses mutagenesis and other molecular biology approaches to generate constructs that can be studied using electrophysiological, biochemical and imaging approaches.Epithelial transport, chloride channels, ATP release, cystic fibrosis, interstitial cystitis