John H. White, PhD
Primary Axis:
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Secondary Axis:
Musculoskeletal Disorders Research Focus:
Research aims to understand the molecular mechanisms of the anticancer properties of vitamin D3 analogs using genomics approaches; and evaluate structure function analyses of LCoR, a novel coregulator of nuclear receptor gene regulation identified in the laboratory.Gene expression profiling, genomics, cancer therapeutics, estrogen receptor, vitamin D receptor, regulation of transcription
Email:
Email contact form Keywords:
Gene expression profiling, genomics, cancer therapeutics, estrogen receptor, vitamin D receptor, regulation of transcription
Location:
McIntyre Medical Building Publications:
Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VKM, Yang XJ, White, J.H. Ligand-dependent corepressor LCoR functions by histone deacetylase-dependent and –independent mechanisms. Molecular Cell 2003; 11: 139-150.
Lin R, Nagai Y, Sladek R, Bastien Y, Ho J, Petrecca K, Sotiropoulou G, Diamandis EP, Hudson T, White JH. Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 signaling on cell proliferation, differentiation and immune system regulation. Molecular Endocrinology 2002; 16: 1243-1256.
Prudencio J, Akutsu N, Wong T, Bastien Y, Lin R, Black MJ, Alaoui-Jamali M, White JH. Action of low calcemic 1,25-dihydroxyvitamin D3 analog EB1089 in head and neck squamous cell carcinoma. Journal of the National Cancer Institute 2002; 93: 745-753.
