John Di Battista, PhD

Primary Axis: 
Musculoskeletal Disorders
Email: 
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Research Focus: 

Our research program is focused on the cellular (signaling) and molecular (gene regulation) mechanisms regulating the various components of the inflammatory response using both in vitro and in vivo experimental approaches. The studies have elucidated novel mechanisms involving highly coordinated post-transcriptional and translational control of target genes (e.g. TNF-_, IL-1ß, etc.). In addition, we have revealed the level to which signaling cascades are integrated (scaffolding) in the coordination of cellular responses to inflammatory (extracellular) stimuli. This research program has provided the conceptual framework for identifying new therapeutic targets for the treatment of arthritis and related inflammatory diseases.Arthritis and inflammatory diseases, regulation of gene expression, inflammatory mediators, cell and molecular biology, eicosanoids and cytokines, proteomics and genomics

Keywords: 
Arthritis and inflammatory diseases, regulation of gene expression, inflammatory mediators, cell and molecular biology, eicosanoids and cytokines, proteomics and genomics
Location: 
Royal Victoria Hospital
Publications:
Faour W, Mancini A, He QW, Di Battista JA. T-cell derived interleukin-17 regulates the level and stability of cyclooxygenae-2 (COX-2) mRNA through specific activation of the p38 mitogen-activated protein kinase cascade in target cells. Role of distal sequences in the 3' untranslated region of COX-2 mRNA. Journal Biology Chemistry 2003; 278: 26897-26907.
Kalajdzic T, Faour WH, He QW, Martel-Pelletier J, Pelletier J-P, Di Battista JA. Nimesulide, a preferential cyclooxygenase-2 inhibitor, suppresses peroxisome-proliferator activated receptor induction of cyclooxygenase-2 gene expression in human synovial fibroblasts: Evidence for receptor antagonism. Arthritis & Rheumatology 2002; 46: 494-506.
Faour, WH, He Y, de Ladurantaye M, He W, Quintero M, Mancini A, Di Battista JA. Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1ß-treated human synovial fibroblasts. Journal of Biological Chemistry 2001; 276: 31720-31731.