Jean Ouellet, MD, FRCSC

Primary Axis: 
Musculoskeletal Disorders
Email: 
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Research Focus: 

McGill Scoliosis & Spine group has broadened its current research field by amalgamating its biomechanical expertise with new collaborators in the goal to better understand the pathophysiology of spinal ailments. Past spinal research was either mechanical in nature or purely cellular. We are currently involved in research which will assess cellular response to external mechanical forces. We are concentrating our efforts on three specific topics; pathophysiology of progressive spinal deformities in scoliosis, pathophysiology of degenerative disc disease, pathophysiology of pain generating patterns in the spine. With respect to our pure biomechanical project we are currently looking at how to quantify spinal balance and how to predict if we have achieved it intraoperatively. We are currently patenting a tool to help with this particular surgical challenge.

Keywords: 
Scoliosis, degeneration
Publications:
F Mwale, A Petit, G Yao, JA Ouellet, J Antoniou. Effect of parathyroid hormone on type X and type II collagen expression in mesenchymal stem cells from osteoarthritis patients. Tissue Eng. Submitted, February 2010.
Haglund L, Ouellet J and P Roughley, Variation in chondroadherin abundance and fragmentation in the human scoliotic disc. Spine, 2009 June 15;34(14):1513-8.
F Mwale, CN Demers, P-L Girard-Lauriault, D Stachura, JA Ouellet, A Petit, MR Wertheimer, J Antoniou. Effect of nitrated surfaced on type X collagen expression by growth plate chondrocytes. J Biomed Mater Res. Submitted, February 2010.