Jean-Martin Laberge, MD

Research Focus: 

We are studying the effects of fetal tracheal occlusion in animal models of congenital diaphragmatic hernia (CDH). CDH affects about 1 in 4,500 births and causes death from pulmonary hypoplasia (underdevelopment of the lungs) in 25% of cases when it is detected before birth. Blockage of the trachea before birth may allow enough lung development for survival.

Congenital diaphragmatic hernia, fetal tracheal occlusion, lung growth, pulmonary hypoplasia
Montreal Children's Hospital
Grushka J, Al-Abbad S, Baird R, Puligandla P, Kaplan F and Laberge J-M. The Effect of In Vitro Tracheal Occlusion on Branching Morphogenesis in Fetal Lung Explants from the Rat Nitrofen CDH Model. J Pediatr Surg. 45:943-994; 2010
Grushka JR, Laberge J-M, Puligandla P, Skarsgard ED, and the Canadian Pediatric Surgery Network. The effect of hospital case volume on outcome in congenital diaphragmatic hernia (CDH): The experience of the Canadian Pediatric Surgery Network. J Pediatr Surg 44:873-876; 2009
Weinsheimer RL, Yanchar NL, Bouchard SB, Kim PK, Laberge J-M, Skarsgard ED, Lee SK, McMillan D, von Dadelszen P, and the Canadian Pediatric Surgery Network. Gastroschisis closure – does method really matter? J Pediatr Surg, 43:874-878; 2008
Baird R, Khan N, Laberge J-M, Flageole H, Anselmo M, Puligandla P. The effect of tracheal occlusion on lung branching in the rat nitrofen CDH model. J Surg Research, 148:224-229; 2008
Bratu I, Butter A, Piedboeuf B, Flageole H, Laberge J-M, Kovacs L, Faucher D: Fetal Tracheal Occlusion in lambs with congenital diaphragmatic hernia: Role of exogenous surfactant at birth. Pediatric Research 58: 689-694; 2005
Piedboeuf B, Flageole H, Laberge J-M, Cloutier M, Seaborn T, Bratu I. Effect of temporary tracheal occlusion on the endothelin system in experimental cases of diaphragmatic hernia. Experimental Lung Research 31: 391-404; 2005