Jean-Martin Laberge, MD

Research Focus: 

We are studying the effects of fetal tracheal occlusion in animal models of congenital diaphragmatic hernia (CDH). CDH affects about 1 in 4,500 births and causes death from pulmonary hypoplasia (underdevelopment of the lungs) in 25% of cases when it is detected before birth. Blockage of the trachea before birth may allow enough lung development for survival.

Keywords: 
Congenital diaphragmatic hernia, fetal tracheal occlusion, lung growth, pulmonary hypoplasia
Location: 
Montreal Children's Hospital
Publications:
Grushka J, Al-Abbad S, Baird R, Puligandla P, Kaplan F and Laberge J-M. The Effect of In Vitro Tracheal Occlusion on Branching Morphogenesis in Fetal Lung Explants from the Rat Nitrofen CDH Model. J Pediatr Surg. 45:943-994; 2010
Grushka JR, Laberge J-M, Puligandla P, Skarsgard ED, and the Canadian Pediatric Surgery Network. The effect of hospital case volume on outcome in congenital diaphragmatic hernia (CDH): The experience of the Canadian Pediatric Surgery Network. J Pediatr Surg 44:873-876; 2009
Weinsheimer RL, Yanchar NL, Bouchard SB, Kim PK, Laberge J-M, Skarsgard ED, Lee SK, McMillan D, von Dadelszen P, and the Canadian Pediatric Surgery Network. Gastroschisis closure – does method really matter? J Pediatr Surg, 43:874-878; 2008
Baird R, Khan N, Laberge J-M, Flageole H, Anselmo M, Puligandla P. The effect of tracheal occlusion on lung branching in the rat nitrofen CDH model. J Surg Research, 148:224-229; 2008
Bratu I, Butter A, Piedboeuf B, Flageole H, Laberge J-M, Kovacs L, Faucher D: Fetal Tracheal Occlusion in lambs with congenital diaphragmatic hernia: Role of exogenous surfactant at birth. Pediatric Research 58: 689-694; 2005
Piedboeuf B, Flageole H, Laberge J-M, Cloutier M, Seaborn T, Bratu I. Effect of temporary tracheal occlusion on the endothelin system in experimental cases of diaphragmatic hernia. Experimental Lung Research 31: 391-404; 2005