Janet Henderson, PhD
Primary Axis:
Musculoskeletal Disorders
Email:
Email contact form Research Focus:
Similar molecular pathways regulate cartilage and bone development and repair. Our research is focused on understanding how the pathways linked to skeletal growth factors interact to regulate these processes and how the pathways become de-regulated in age-related disorders such as osteoporosis and osteoarthritis.Skeletal phenotyping, cartilage and bone cells, growth factor signaling, cell proliferation and differentiation, cellular aging, apoptosis
External Website:
External Website Keywords:
Skeletal phenotyping, cartilage and bone cells, growth factor signaling, cell proliferation and differentiation, cellular aging, apoptosis
Location:
740 Penfield Publications:
Aarts MM, Davidson D, Corluka A, Petroulakis E, Guo J, Bringhurst FR, Galipeau J, Henderson JE. PTHrP promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis. Journal of Biological Chemistry 2001; 276: 37934-37943.
Amizuka N, Davidson D, Liu H, Valverde-Franco G, Chai S, Sasaki T, Ozawa H, Hammond V, Ornitz DM, Goltzman D, Henderson JE. Signaling by fibroblast growth factor receptor 3 (FGFR3) and parathyroid hormone related protein (PTHrP) coordinate cartilage and bone development. Bone 2004; 34: 13-25.
Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, Ornitz DM, Henderson JE. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Human and Molecular Genetics 2004; 13: 271-284.
