James Engert, PhD
Primary Axis:
Cardiovascular Diseases and Critical Care
Secondary Axis:
Medical Genetics and Genomics
Email:
Email contact form Research Focus:
Dr. Engert’s primary research interest is the genetics of heart disease, as well as conditions that lead to heart disease such as obesity and diabetes. Data from high throughput genotyping of single nucleotide polymorphisms (SNPs) will allow for large-scale association studies as well as linkage disequilibrium mapping in patient populations from around the world. Current studies focus on ethnic differences in risk and Gene-Environment interactions.
Keywords:
Atherosclerosis, haplotypes, association studies, linkage disequilibrium,single nucleotide polymorphisms (SNPs), genotyping, Gene-Environment interaction
Location:
Royal Victoria Hospital Publications:
Do R, Bailey SD, Paré G, Montpetit A, Desbiens K, Hudson TJ, Yusuf S, Bouchard C, Gaudet D, Pérusse L, Anand S, Vohl MC, Pastinen T, Engert JC, Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels. Circ Cardiovasc Genet. 3(5):454-461; Oct 2010
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S; DREAM investigators, Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care. 33(10):2250-2253; Oct 2010
St Germaine CG, Bogaty P, Boyer L, Hanley J, Engert JC, Brophy JM, Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. Am J Cardiol. 105(12):1740-1745; 15 Jun 2010
Couillard C, Vohl M-C, Engert JC, Lemieux I, Houde A, Alméras N, Prud'homme D, Nadeau A, Després JP and Bergeron J. Effect of Apolipoprotein CIII Gene Polymorphisms on the Lipoprotein-Lipid Profile of Viscerally Obese Men. Journal of Lipid Research 44: 986-993; 2003
Engert JC, Vohl M-C, Williams SM, Lepage P, Faith J, Doré C, Renaud Y, Villeneuve A, Després JP, Gaudet D, Hudson TJ. 5' Flanking variants of resistin are associated with obesity. Diabetes; 51: 1629-1634; 2002
Zwarts KY, Clee SM, Zwinderman AH, Engert JC, Singaraa R, Loubser O, James E, Roomp K, Hudson TJ, Jukema JW, Kastelein JJP, Hayden MR. ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels. Clinical Genetics; 61: 115-125; 2002
