Hélène Perrault, PhD, MSc

Primary Axis: 
Respiratory Health
Email: 
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Research Focus: 

Research involves cross-disciplinary collaboration with respirologists, epidemiologists and basic scientists to advance knowledge on exercise intolerance, mechanism of disease and the role of exercise interventions in the clinical management of individuals with chronic respiratory diseases. Current research projects target the energy demands of physical activities of daily life in patients with various degrees of chronic obstructive lung disease including circulatory - respiratory physiological interactions as limiting factors for peripheral oxygen delivery and skeletal muscle oxygen utilization in the exercise intolerance of these patients.COPD; exercise intolerance; cardiac output; peripheral flow limitation; dynamic hyperinflation; mechanical efficiency

Keywords: 
COPD; exercise intolerance; cardiac output; peripheral flow limitation; dynamic hyperinflation; mechanical efficiency
Location: 
Montreal Chest Institute
Publications:
Maltais F., J. Bourbeau., Y. Lacasse., S. Shapiro S., H. Perrault., J.R. Penrod, M. Baltzan, M. Rouleau, M. Julien, B. Paradis, R. Audet, P. Hernandez, R. D. Levy, P.Camp, R. Lecours, D. Picard, S. Bernard. A Canadian, multicentre, randomized clinical trial of home-based pulmonary rehabilitation in chronic obstrctive pulmonary disease : Rationale and methods. Can. Resp. J. 12 (4) 193-198, 2005.
Scott A, Eberhard A, Ofir D, Pham Dinh T, Calabrese P, Benchetrit G, Lesiuk V, and Perrault H. Enhanced cardiac vagal efferent activity does not explain training-induced bradycardia”. Autonomic Neuroscience: Basic and Clinical 2004; 112: 60-68.
Ben Lamine S., Calabrese P., Perrault H., Pham Dinh T, Eberhard A. and G. Benchetrit. Individual Differences in Respiratory Sinus Arrhythmia? Am. J. Physiol. Heart. Circ. Physiol. 2004: 286: H2305-13.
Perrault H., D. Johnson, Kouame N'Guessan, A. Cloutier, Chartrand C, A. Davignon, Cléroux J. Resetting of baroreflex function in patients successfully operated for Tetralogy of Fallot. Can J Cardiol. 19(2): 145-150, 2003.
Aguilaniu B., H. Perrault, Flore P., Page E., J.R. Lacour. Early onset of pulmonary gas exchange disturbance during progressive exercise in healthy active men. J. Appl Physiol. 92: 1879-1884, 2002.
Delobbe A., Maitre J., Perrault H., Flore P., Page E., Sayah H., Wallaert B. and Aguilaniu B. Impaired exercise response in sarcoid patients with normal pulmonary function. Sarcoidosis Vasc Diffuse Lung Dis.; 19 (2): 148-53, 2002.
Perrault H., Tzovanis M, Johnson D., Davignon A., C. Chartrand, A. Kader., R.A. Nadeau. Autonomic characteristics following surgical repair of tetralogy of Fallot using heart rate and blood pressure variability. Pediatric Exercise Science, 13, 47-59, 2001.
Marchand I.*, Perrault H., Johnson D., G. R. Brisson, D. Montgomery. Gender differences in temperature and vascular characteristics during exercise recovery. Can. J. Appl. Physiol. 26(5): 425-441, 2001.
Johnson D., Perrault H., Vobecky S, Trudeau F., Delvin J., Fournier A., Davignon A. Resetting of the cardiopulmonary baroreflex 10 years after surgical repair of coarctation of the aorta. Heart, 85, 318-325, 2001.
Calabrese P*., H. Perrault PhamDinh T., Eberhard A., Benchetrit G. Cardiorespiratory interactions during resistive load breathing. Am. J. Physiol. 279: R2208-R2213, 2000.
Bourbeau J. & Perrault H. Physiologic basis for rehabilitation in COPD. In: The Physiologic Basis of Respiratory Disease. Editors: Hamid Q, Martin J.G, Shannon J. The Physiologic Basis of Respiratory Disease. , Chap. 65. B.C. Decker Inc. (In press – expected date of publication August 2005).
Aguilaniu B & Perrault H. Exploration de l'intolérance à l'exercice. In: Bronchopneumopathies chroniques obstructives. G. Huchon et N. Roches editeurs. Chap. 13, pp 339-362, Editions Margauxorange, Paris, 2003.