Geoffrey Hendy, PhD
Primary Axis:
Musculoskeletal Disorders
Email:
Email contact form Research Focus:
Research is concerned with understanding parathyroid function in health and disease. Molecular genetic analysis are made of the calcium-sensing receptor that acts as a “calciostat” to sense blood calcium levels and regulate parathyroid cell growth. The cell signaling pathways implicated in parathyroid tumorigenesis caused by inactivation of the tumor suppressor, menin, encoded by the multiple endocrine neoplasia type 1 gene, are being elucidated.Parathyroid gland, calcium-sensing receptor, parathyroid cell growth, menin, calcium homeostasis
External Website:
External Website Keywords:
Parathyroid gland, calcium-sensing receptor, parathyroid cell growth, menin, calcium homeostasis
Location:
Royal Victoria Hospital Publications:
Canaff L, Hendy GN. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1β. Journal of Biological Chemistry 2005; 280:14177-14188.
Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN. Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia. Human Molecular Genetics 2005; 14:1679-1690.
Hendy GN, Kaji H, Sowa H, Lebrun J-J, Canaff L. Menin and TGF-β superfamily member signaling via the Smad pathway in pituitary, parathyroid and osteoblast. Hormones and Metabolic Research 2005; 37:375-379.
