Emil Skamene, MD, PhD

Research focuses on the genetic dissection of complex inflammatory disorders. Towards this aim, a panel of recombinant congenic mouse strains have been developed which expedite the mapping and isolation of genes controlling complex traits. Research results have led to the identification of the pivotal role of the macrophage in host defense to infection, and to the identification of human genes controlling susceptibility to infectious diseases, such as tuberculosis, leprosy, and malaria.Mouse models, immunogenetics, complex traits, tuberculosis, leprosy, asthma, malaria, translational immunology