David Eidelman, MD

Primary Axis: 
Respiratory Health
Research Focus: 

Research is focused on the role of nitric oxide and oxidative stress in the pathogenesis of inflammatory airway diseases including asthma and cystic fibrosis. The lab is particularly focused on understanding how nitric oxide influences cellular function by modulating cell signaling and contributing to post-translational modification of proteins. The laboratory uses analytic chemistry and cell and molecular approaches to investigate both animal models and cell culture systems.Asthma, cystic fibrosis, nitric oxide, glutathione, nitrosothiols, peroxidases, airway epithelium, airway smooth muscle.

Keywords: 
Asthma, cystic fibrosis, nitric oxide, glutathione, nitrosothiols, peroxidases, airway epithelium, airway smooth muscle.
Location: 
Royal Victoria Hospital
Publications:
Govindaraju K, Govindaraju V, Eidelman DH. Analysis of glutathione in rat airway surface liquid by capillary zone electrophoresis with conductivity detection. Journal of Chromatography B: Biomedical Sciences and Applications 2003; 788: 369-376.
Duguet A, Iijima H, Eum SY, Hamid Q, Eidelman DH. Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice. American Journal of Respiratory and Critical Care Medicine 2001; 164: 1119-1126.
Iijima H, Duguet A, Eum SY, Hamid Q, Eidelman DH. Nitric oxide and protein nitration are eosinophil dependent in allergen-challenged mice. American Journal of Respiratory and Critical Care Medicine 2001; 163: 1233-1240.