Cynthia Gates Goodyer, PhD
Primary Axis:
Human Reproduction and Development
Email:
Email contact form Research Focus:
Research objectives include: To determine the factors regulating expression of the human growth hormone receptor (hGHR) gene during pre- and post-natal development. To investigate changes in the hGHR intracellular signalling pathways during development. To characterize the role of mutations or polymorphisms in the hGHR gene or changes in the hGHR signalling pathways that can explain disorders of growth in fetal and postnatal individuals, including short stature and obesity. To determine the extent and effect of prenatal exposure to persistent organic pollutant (POP) environmental contaminants (e.g. flame retardants) on fetal development and reproductive health.
Keywords:
Human growth, gene regulation, growth hormone, growth hormone receptor, idiopathic short stature, obesity, endocrine disruptors, brominated flame retardants, human fetal development, reproductive health
Location:
Montreal Children's Hospital Publications:
Kenth, G., Puzhko, S. and Goodyer, C.G. Human growth hormone receptor gene expression is regulated by Gfi-1/Gfi-1b and GAGA cis-elements. Mol Cell Endocrinol 335: 135-147; 2011
Erman, A., Veilleux, A., Tchernof, A. and Goodyer, C.G. Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA levels are reduced in omental and subcutaneous adipose tissues of obese women. Int J Obesity (2011, in press).
Erman, A., Wabitsch, M. and Goodyer, C.G. Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors. Int J Obesity (2011, in press).
Wei, Y.*, Wabitsch, M. and Goodyer, C.G. Structure and Activity of the human growth hormone receptor gene V2 promoter. Molecular Endocrinology 23: 360-372; 2009
Wei, Y.*, Puzhko, S.+, Wabitsch, M. and Goodyer, C.G. Transcriptional regulation of the human growth hormone receptor gene V2 promoter by transcriptional activators and repressor. Molecular Endocrinology 23: 373-387; 2009
Doucet, J., Tague, B., Arnold, D.L., Cooke G., Hayward, S. and Goodyer, C.G. Persistent organic pollutant residues in human fetal liver and placental tissues from Greater Montreal, Quebec: a longitudinal study from 1998-2006. Environmental Health Perspectives 117: 605-610; 2009
