Christian Rocheleau, PhD

Primary Axis: 
Cancer
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Dr. Rocheleau's lab uses the nematode Caenorhabditis elegans, as a genetic model organism, to study the molecular and cellular functions of genes implicated in human disease. In particular, the team is interested in understanding how signaling through the Ras/MAPK pathway is regulated in the context of the whole organism. Studies involve the mechanisms, by which protein scaffolds, vesicular trafficking and an endogenous RNAi-like pathway can regulate Ras/MAPK signaling during development. Discoveries made using C. elegans will ultimately be applied to mammalian systems to identify new drug targets for the treatment of human diseases.Caenorhabditis elegans, signaling transduction, Ras/MAPK signaling, vesicular trafficking, small RNAs

External Website: 
External Website
Keywords: 
Caenorhabditis elegans, signaling transduction, Ras/MAPK signaling, vesicular trafficking, small RNAs
Location: 
Strathcona Anatomy and Dentistry
Publications:
Chotard L, Skorobogata O, Sylvain MA, Shrivastava S, and Rocheleau CE. TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans. PLoS ONE, 5, e15662; 2010
Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG, and Rocheleau CE. TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in C. elegans. Mol. Biol. Cell, 21, 2285-2296; 2010
Rocheleau CE, Cullison K, Huang K, Bernstein Y, Spilker AC and Sundaram MV. The Caenorhabditis elegans ekl (Enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Genetics 178: 1431-1443; 2008
Rocheleau CE, Ronnlund A, Tuck S, and Sundaram MV. Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc Natl Acad Sci USA 120: 11757-11762; 2005
Rocheleau CE, Howard RM, Goldman AP, Volk ML, Girard LJ, Sundaram MV. A lin-45 raf enhancer screen identifies eor-1, eor-2, and unusual alleles of Ras pathway genes in Caenorhabditis elegans. Genetics 161: 121-131; 2002