Anie Philip, PhD

Primary Axis: 
Musculoskeletal Disorders
Secondary Axis: 
Cancer
Email: 
Email contact form
Research Focus: 

Research is focused on studies of TGF-beta signaling and action in the skin and cartilage. Dysregulation of TGF-beta action has been implicated in impaired wound healing, hypertrophic scarring, and in diseases such as psoriasis, scleroderma, and osteoarthritis. We use a variety of cellular and molecular approaches to understand the mechanisms involved in TGF-beta signaling and the regulation of TGF-beta action. These studies are aimed at developing novel strategies for the treatment of the above skin and cartilage disorders.Skin, Cartilage, TGF-beta, receptors, signaling, scarring, fibrosis, psoriasis, scleroderma, osteoarthritis

Keywords: 
Skin, Cartilage, TGF-beta, receptors, signaling, scarring, fibrosis, psoriasis, scleroderma, osteoarthritis
Location: 
Montreal General Hospital
Publications:
Parker WL, Soe-Lin H, Knaus P, Philip A. Expression and function of TRII-B, a variant of the type II TGF- receptor, in human chondrocytes. Osteoarthritis and Cartilage 2006. (In Press).
Cadot C, Poirier D, Philip A. First synthesis of a steroid containing an unstable 19- nor-androsta-1,5-dien-3one system. Tetrahedron 2006; 62: 4384-4392.
Finnson K, Tam B, Liu K, Marcoux A, Lepage P, Roy S, Philip, A. Identification of CD109 as part of TGF- receptor system in human keratinocytes. FASEB J 2006; 20: E780-E795.