Andrey Cybulsky, MD
Primary Axis:
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Email:
Email contact form Research Focus:
Mechanisms of immune glomerular cell injury and proteinuria. Role of phospholipases, protein kinases, and stress proteins. 2) Role of SLK (a Ste-20-like kinase) in renal ischemia-reperfusion injury. Mechanisms/regulation of kinase activation, signaling effectors, functional effects, including apoptotic pathways. 3) Regulation of protein kinase signaling by extracellular matrix in the glomerulus. Activation of protein kinases, mediators of apoptosis/cell survival.Arachidonic acid, complement, glomerulonephritis, phospholipases, protein kinases, signal transduction
External Website:
External Website Keywords:
Arachidonic acid, complement, glomerulonephritis, phospholipases, protein kinases, signal transduction
Location:
Royal Victoria Hospital Publications:
Cohen D, Papillon J, Aoudjit L, Li H, Cybulsky AV, Takano T. Role of calcium-independent phospholipase A2 in complement-mediated glomerular epithelial cell injury. Am J Physiol 294: F469-F479; 2008.
Cybulsky AV, Takano T, Papillon J, Hao W, Mancini A, Di Battista JA, Cybulsky MI. The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression. Am J Physiol 292: F845-F852; 2007.
Cybulsky AV, Takano T, Guillemette J, Papillon J, Volpini RA, Di Battista JA. The Ste20-like kinase, SLK, promotes p53 transactivation and apoptosis.Am J Physiol. 2009, 297, F971-F980.
Ren G, Huynh C, Bijian K, Cybulsky AV. Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury. Mol Immunol 45: 2236-2246; 2008.
