Alain Nepveu, PhD
Research focuses on the regulation of transcription in mammalian cells and, in particular, how it contributes to the initiation and progression of cancer. Additional research combines a vast array of molecular biology and functional genomic approaches together with tissue culture and mouse models to investigate the biological roles of the CUX1 transcription factor: progression from the G1 to the S phase of the cell cycle; regulation of the spindle assembly checkpoint during mitosis and promotion of genomic instability; autocrine activation of the Wnt/beta-catenin pathway in cancers of the breast and other tissues; cooperation with ras oncogenes in tumor initiation and progression; DNA damage responses: double-strand break repair choice and generation of point mutations.
